5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

Base Information

Chemical Name:5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester
CAS No.:335119-28-3
Molecular Formula:C₂₀H₃₀O₄S₂
Molecular Weight:398.588
Hs Code.:

Synonyms:5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

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Chemical Property of 5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

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Technology Process of 5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

There total 1 articles about 5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 109-80-8
1.3-propanedithiol

: (4-benzyloxy-6-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-yl)-acetic acid methyl ester

: 335119-28-3
5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In nitromethane; at -20 - -15 ℃; for 0.5h;
DOI:10.1021/ol015551o

Reference yield: 94.0%

: 540-88-5
acetic acid tert-butyl ester

: 335119-28-3
5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

: 335119-31-8
7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 2h;
DOI:10.1021/ol015551o

Reference yield:

: 335119-28-3
5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

: 7-benzyloxy-8-[1,3]dithian-2-yl-3,5-dihydroxy-8-methyl-nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LDA / tetrahydrofuran / 2 h / -78 - 0 °C

2: Me₄NBH(OAc)3 / acetonitrile; acetic acid / 96 h / -35 - -25 °C

With tetramethylammonium triacetoxyborohydride; lithium diisopropyl amide; In tetrahydrofuran; acetic acid; acetonitrile; 1: Claisen condensation;
DOI:10.1021/ol015551o