5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine
CAS No.:936743-52-1
Molecular Formula:C₄₈H₃₈N₂O₇
Molecular Weight:754.839
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 31067-63-7
9-(buta-1,3-diynyl)anthracene

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 936743-52-1
5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

Guidance literature:: With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2006.10.090

Reference yield:

: 1564-64-3
9-Bromoanthracene

: 936743-52-1
5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / triethylamine; CuI; PPh₃ / Pd(PPh₃)2Cl₂ / 4 h / Heating

2: 87 percent / potassium hydroxide / toluene / 0.42 h / 115 °C

3: 63 percent / n-butylamine; CuI / (Ph₃P)4Pd / toluene / 20 °C

4: 63 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h

5: 80 percent / CuI; triethylamine / (Ph₃P)4Pd / dimethylformamide / 20 °C

With potassium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; N-butylamine; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 5: Sonogashira coupling;
DOI:10.1016/j.tet.2006.10.090

Reference yield:

: 13752-40-4
9-ethynylanthracene

: 936743-52-1
5'-O-(4,4'-dimethoxytrityl)-5-[4-(9-anthracenyl)buta-1,3-diynyl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / n-butylamine; CuI / (Ph₃P)4Pd / toluene / 20 °C

2: 63 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h

3: 80 percent / CuI; triethylamine / (Ph₃P)4Pd / dimethylformamide / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; N-butylamine; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3: Sonogashira coupling;
DOI:10.1016/j.tet.2006.10.090