(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

Base Information

Chemical Name:(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine
CAS No.:272772-31-3
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

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Technology Process of (+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

There total 1 articles about (+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 106-38-7
para-bromotoluene

: 95715-87-0,102308-32-7,144070-30-4,127589-93-9
tert-butyl 4-formyl-2,2-dimethyloxazolidine-3-carboxylate

: 272772-31-3
(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

Guidance literature:: para-bromotoluene; With magnesium; In tetrahydrofuran;

tert-butyl 4-formyl-2,2-dimethyloxazolidine-3-carboxylate; In tetrahydrofuran; at 20 ℃; for 7h;

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 272772-31-3
(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

: 272772-32-4
(+/-)-3-N-tert-butoxycarbonyl-2,2-dimethyl-4-[(4-methylphenyl)(tert-butyldiphenylsiloxy)methyl]-1,3-oxazolidine

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 60 ℃; for 72h;

Reference yield:

: 272772-31-3
(+/-)-3-(N-tert-butoxycarbonyl)-2,2-dimethyl-4-[(4-tolyl)hydroxymethyl]-1,3-oxazolidine

: 52074-58-5
ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / imidazole; 4-dimethylaminopyridine / dimethylformamide / 72 h / 60 °C

2: 79 percent / aq. AcOH / tetrahydrofuran / 24 h / 35 °C

3: 87 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / 20 °C

4: 100 percent / tetrahydrofuran / 24 h / 20 °C

5: 95 percent / NaH in mineral oil / dimethylformamide / 1.5 h / 0 °C

6: 86 percent / tetrabutylammonium fluoride; acetic acid / tetrahydrofuran / 216 h / 40 °C

7: Dess-Martin periodinane / CH₂Cl₂ / 0.42 h / 20 °C

8: 69 percent / 97 percent concd. sulfuric acid; silica gel / CH₂Cl₂ / 2 h / 0 - 20 °C

With 1H-imidazole; dmap; sulfuric acid; tetrabutyl ammonium fluoride; silica gel; sodium hydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Etherification / 2: Ring cleavage / 3: Oxidation / 4: Alkylation / 5: Methylation / 6: desilylation / 7: Oxidation / 8: Decarboxylation;