Homomorpholine hydrochloride

Base Information

• Chemical Name: Homomorpholine hydrochloride
• CAS No.: 178312-62-4
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.609
• Hs Code.: 2934999090
• Mol file: 178312-62-4.mol

Synonyms:1,4-Oxazepine,hexahydro-, hydrochloride (9CI);1,4-Oxazepan hydrochloride;Hexahydro-1,4-oxazepine hydrochloride;

Chemical Property of Homomorpholine hydrochloride

Chemical Property:

• Vapor Pressure: 0.328mmHg at 25°C
• Melting Point: 156-154 °C
• Boiling Point: 196.9 °C at 760 mmHg
• Flash Point: 72.9 °C
• PSA: 21.26000
• Density: 0.909g/cm3
• LogP: 1.12710
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

HomomorpholineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-20/21-34-65-41-37/38
• Safety Statements: 16-26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Homomorpholine Hydrochloride is a useful synthetic intermediate. It is used to prepare homomorpholine oxazolidinone with antibacterial activities. It is also used to synthesize A2A adenosine receptor antagonists for the treatment of Parkinson's disease.

Technology Process of Homomorpholine hydrochloride

There total 1 articles about Homomorpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ homomorpholine hydrochloride (178312-62-4)

Guidance literature:

Reference yield: 89.28%

2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine (5466-43-3) + homomorpholine hydrochloride (178312-62-4) → 4-[2-chloro-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl]-1,4-oxazepane

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 3h;

Reference yield: 70.4%

(1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone (1227065-24-8) + homomorpholine hydrochloride (178312-62-4) → (4-(3-(1,4-oxazepan-4-yl)pyrazin-2-yloxy)phenyl)(1H-benzo[d]imidazol-2-yl)methanone (1227065-44-2)

Guidance literature:

In dimethyl sulfoxide; at 70 ℃; for 5h; Sealed tube;

DOI:10.1021/jm401234w

Downstream raw materials:

1,4-oxazepane

ethyl 4-{[4-(1,4-oxazepan-4-ylmethyl)phenyl]ethynyl}benzoate

(2S)-N,2-dimethyl-2-[methyl(4-{[4-(1,4-oxazepan-4-ylmethyl)phenyl]ethynyl}benzoyl)amino]-N'-(tetrahydro-2H-pyran-2-yloxy)propanediamide

(4-(3-(1,4-oxazepan-4-yl)pyrazin-2-yloxy)phenyl)(1H-benzo[d]imidazol-2-yl)methanone

Refernces