dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Base Information

Chemical Name:dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]
CAS No.:21735-83-1
Molecular Formula:C₁₁H₁₂Cl₂N₂O₄
Molecular Weight:307.133
Hs Code.:

dichloroacetic acid-[(1<i>R</i>,2<i>R</i>)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Synonyms:dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Suppliers and Price of dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Chemical Property:

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Technology Process of dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

There total 3 articles about dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 133227-81-3
Toluene-4-sulfonic acid (2R,3R)-2-(2,2-dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propyl ester

: 21735-83-1
dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.3h;
DOI:10.1021/ja00128a006

Reference yield:

: 56-75-7,85666-84-8
chloramphenicol

: 21735-83-1
dichloroacetic acid-[(1R,2R)-2-hydroxy-1-methyl-2-(4-nitro-phenyl)-ethylamide]

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / pyridine / 2 h / Ambient temperature

2: 17 percent / LiAlH₄ / tetrahydrofuran / 2.3 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1021/ja00128a006