4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride

Base Information

• Chemical Name: 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride
• CAS No.: 42381-27-1
• Molecular Formula: C9H15N3O2S^.HCl
• Molecular Weight: 265.764
• Hs Code.: 2935009090
• Mol file: 42381-27-1.mol

Synonyms:Benzeneethanesulfonamide,4-hydrazino-N-methyl-, monohydrochloride (9CI);p-[b-(Methylsulfonamido)ethyl]phenylhydrazinehydrochloride;

Chemical Property of 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride

Chemical Property:

• Appearance/Colour: yellow to light yellow crystal powder
• Vapor Pressure: 7.79E-09mmHg at 25°C
• Boiling Point: 459.2 °C at 760 mmHg
• Flash Point: 231.5 °C
• PSA: 92.60000
• LogP: 3.11090

Purity/Quality:

99% ^*data from raw suppliers

4-Hydrazinyl-N-methylbenzeneethanesulfonamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the preparation of antimigraine drug Naratriptan (N378730). Naratriptan intermediate

Technology Process of 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride

There total 3 articles about 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(4-amino-phenyl)ethanesulfonic acid methylamide (98623-16-6) → 2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride (42381-27-1)

Guidance literature:

2-(4-amino-phenyl)ethanesulfonic acid methylamide; With sodium nitrite;

With hydrogenchloride; tin(ll) chloride;

Reference yield: 67.0%

→ 4-[2-(3-Cyanopropylidene)hydrazino]-N-methyl-benzeneethanesulphonamide + 2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride (42381-27-1)

Guidance literature:

Reference yield: 66.0%

→ 2-(4-hydrazinylphenyl)-N-methylethane-1-sulfonamide hydrochloride (42381-27-1)

Guidance literature:

upstream raw materials:

2-(4-amino-phenyl)ethanesulfonic acid methylamide

Downstream raw materials:

C₁₇H₁₉N₃O₂S₂

C₁₉H₁₈F₃N₃O₂S

C₂₀H₂₀F₃N₃O₂S

2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide

Refernces

• 1、 -. "5-substituted-3-aminoalkyl indole derivatives for migraine". . . Retrieved 2008/06/13.