5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene

Base Information

• Chemical Name: 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene
• CAS No.: 868773-81-3
• Molecular Formula: C₂₇H₂₃BrO₃S
• Molecular Weight: 507.448
• Mol file: 868773-81-3.mol

Synonyms:5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene

Chemical Property of 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene

There total 2 articles about 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-bromo-5-hydroxy-2,3-dimethylbenzo[b]thiophene (868773-86-8) + 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol (101597-25-5) → 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene (868773-81-3)

Guidance literature:

With acidic alumina Brockmann I; In toluene; at 80 ℃; for 0.25h;

DOI:10.1021/ol051378a

Reference yield:

5-methoxy-2,3-dimethylbenzo[b]thiophene (91142-36-8) → 5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene (868773-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Br₂; Fe / diethyl ether / 0.5 h

1.2: 0.195 g / BBr₃ / CH₂Cl₂ / 2 h / Heating

2.1: 70 percent / acidic alumina Brockmann I / toluene / 0.25 h / 80 °C

With acidic alumina Brockmann I; bromine; iron; In diethyl ether; toluene;

DOI:10.1021/ol051378a

Reference yield: 70.0%

5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene (868773-81-3) + Boc-Ala(N-Boc)-β-(4-aminophenylsulfanyl)-OMe (439611-60-6) → methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate (868773-82-4)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 3h;

DOI:10.1021/ol051378a

upstream raw materials:

6-bromo-5-hydroxy-2,3-dimethylbenzo[b]thiophene

1,1-bis(4-methoxyphenyl)-2-propyn-1-ol

5-methoxy-2,3-dimethylbenzo[b]thiophene

Downstream raw materials:

methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate