methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

Base Information

Chemical Name:methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate
CAS No.:868773-82-4
Molecular Formula:C₄₇H₅₂N₂O₉S₂
Molecular Weight:853.07
Hs Code.:

Synonyms:methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

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Chemical Property of methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

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Technology Process of methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

There total 5 articles about methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 868773-81-3
5-bromo-7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromene

: 439611-60-6
Boc-Ala(N-Boc)-β-(4-aminophenylsulfanyl)-OMe

: 868773-82-4
methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 3h;
DOI:10.1021/ol051378a

Reference yield:

: 868773-86-8
6-bromo-5-hydroxy-2,3-dimethylbenzo[b]thiophene

: 868773-82-4
methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / acidic alumina Brockmann I / toluene / 0.25 h / 80 °C

2: 70 percent / Pd(OAc)2; BINAP; Cs₂CO₃ / toluene / 3 h / 100 °C

With palladium diacetate; acidic alumina Brockmann I; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;
DOI:10.1021/ol051378a

Reference yield:

: 91142-36-8
5-methoxy-2,3-dimethylbenzo[b]thiophene

: 868773-82-4
methyl 3-{4-[7,7-bis(4-methoxyphenyl)-1,2-dimethyl-7H-thieno[3,2-f]chromen-5-ylamino]phenylthio}-2-[bis(tert-butoxycarbonyl)amino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br₂; Fe / diethyl ether / 0.5 h

1.2: 0.195 g / BBr₃ / CH₂Cl₂ / 2 h / Heating

2.1: 70 percent / acidic alumina Brockmann I / toluene / 0.25 h / 80 °C

3.1: 70 percent / Pd(OAc)2; BINAP; Cs₂CO₃ / toluene / 3 h / 100 °C

With palladium diacetate; acidic alumina Brockmann I; bromine; iron; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In diethyl ether; toluene;
DOI:10.1021/ol051378a