4-Iodotoluene difluoride

Base Information

• Chemical Name: 4-Iodotoluene difluoride
• CAS No.: 371-11-9
• Molecular Formula: C7H7 F2 I
• Molecular Weight: 256.034
• Mol file: 371-11-9.mol

Synonyms:Iodine,difluoro(4-methylphenyl)- (9CI); Toluene, p-(difluoroiodo)- (8CI); Benzene,methyl-, iodine complex; 1-(Difluoroiodo)-4-methylbenzene;4-Methyl(difluoroiodo)benzene; 4-Methyl-1-(difluoroiodo)benzene;Difluoro(4-methylphenyl)iodine; p-(Difluoroiodo)toluene

Chemical Property of 4-Iodotoluene difluoride

Chemical Property:

• Melting Point: 102-106 °C
• PSA: 0.00000
• LogP: 3.44000

Purity/Quality:

98%Min ^*data from raw suppliers

4-IODOTOLUENE DIFLUORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Iodotoluene difluoride

There total 8 articles about 4-Iodotoluene difluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-iodosyl-4-methylbenzene (69180-59-2) → 4-(difluoroiodo)toluene (371-11-9)

Guidance literature:

With hydrogen fluoride; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/ejoc.200400659

Reference yield: 91.0%

4-tolyl iodide (624-31-7) → 4-(difluoroiodo)toluene (371-11-9)

Guidance literature:

With Selectfluor; triethylamine tris(hydrogen fluoride); In [D₃]acetonitrile; at 20 ℃; for 22h; Reagent/catalyst; Concentration; Schlenk technique; Inert atmosphere; Darkness;

DOI:10.1021/acs.joc.7b01671

Reference yield: 66.0%

4-dichloroiodanyl-toluene (19028-26-3) → 4-(difluoroiodo)toluene (371-11-9)

Guidance literature:

With hydrogen fluoride; mercury(II) oxide; In dichloromethane; for 2h;

DOI:10.1039/b209079a

upstream raw materials:

1-iodosyl-4-methylbenzene

4-tolyl iodide

4-dichloroiodanyl-toluene

1-(diacetoxyiodo)-4-methylbenzene

Downstream raw materials:

C₁₈H₂₅F₂IO₂

C₁₅H₁₃F₂I

Refernces

• 1、 Bolm, Carsten,Ma, Ding,Tu, Yongliang,Wang, Chenyang. "Photocatalytic Fluoro Sulfoximidations of Styrenes". supporting information. p. 14134 - 14137. Retrieved 2020/06/17.
• 2、 Doobary, Sayad,Sedikides, Alexi T.,Caldora, Henry P.,Poole, Darren L.,Lennox, Alastair J. J.. "Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates". supporting information. p. 1155 - 1160. Retrieved 2019/12/11.