Technology Process of (3S,8R,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-oxo-8-methyl-9-methoxy-9-(2-hydroxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate
There total 17 articles about (3S,8R,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-oxo-8-methyl-9-methoxy-9-(2-hydroxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 0.0833333h;
DOI:10.1021/ja994003r
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 28.4 g / m-CPBA / CHCl3 / 20 °C
2.1: 94 percent / AcOH; water / (R,R)-salen-Co / 12 h / 20 °C
3.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 °C
3.2: imidazole / dimethylformamide / 20 °C
3.3: 100 percent / iodine / tetrahydrofuran / 0.5 h / 0 °C
4.1: 80 percent / NiCl2; CrCl2 / tetrahydrofuran; dimethylformamide / 20 °C
5.1: 99 percent / Dess-Martin periodinane; pyridine / CH2Cl2 / 0.5 h / 20 °C
6.1: 94 percent / TBAF / tetrahydrofuran / 0.08 h / 0 °C
With
pyridine; chromium dichloride; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; acetic acid; 3-chloro-benzenecarboperoxoic acid; nickel dichloride;
(R,R)-Salen-Co;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;
5.1: Dess-Martin oxidation;
DOI:10.1021/ja002377a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 94 percent / AcOH; water / (R,R)-salen-Co / 12 h / 20 °C
2.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 °C
2.2: imidazole / dimethylformamide / 20 °C
2.3: 100 percent / iodine / tetrahydrofuran / 0.5 h / 0 °C
3.1: 80 percent / NiCl2; CrCl2 / tetrahydrofuran; dimethylformamide / 20 °C
4.1: 99 percent / Dess-Martin periodinane; pyridine / CH2Cl2 / 0.5 h / 20 °C
5.1: 94 percent / TBAF / tetrahydrofuran / 0.08 h / 0 °C
With
pyridine; chromium dichloride; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; acetic acid; nickel dichloride;
(R,R)-Salen-Co;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
4.1: Dess-Martin oxidation;
DOI:10.1021/ja002377a
