3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

Base Information

Chemical Name:3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid
CAS No.:79036-62-7
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

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Chemical Property of 3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

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Technology Process of 3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

There total 6 articles about 3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 79036-63-8
4-Oxo-1-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-2-ene-1,2-dicarboxylic acid diethyl ester

: 79036-62-7
3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 24h; Heating;
DOI:10.1016/S0040-4039(01)90406-X

Reference yield:

: 79036-69-4
5,8-dimethoxy-7-methyl-3,4-dihydro-2H-naphthalen-1-one

: 79036-62-7
3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: DDQ / methanol, reflux, 24 h

2: 1.) NaH 2.) hydrogen / 5percent Pd/C / 1.) benzene, room temp., 4 h 2.) EtOH, room temp.

3: 68 percent / NaH / benzene / 20 h / 55 °C

4: 80 percent / Et₃N / ethanol; benzene / 20 h / Heating

5: 87 percent / Pyrrolidine / AcOH / benzene / 5 h / Heating

6: 95 percent / KOH / ethanol / 24 h / Heating

With pyrrolidine; potassium hydroxide; hydrogen; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; acetic acid; triethylamine; In ethanol; benzene;
DOI:10.1016/S0040-4039(01)90406-X

Reference yield:

: 79036-67-2
3-(1,4,8-Trimethoxy-naphthalen-2-yl)-propionic acid ethyl ester

: 79036-62-7
3-Oxo-6-(1,4,8-trimethoxy-naphthalen-2-ylmethyl)-cyclohex-1-enecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / NaH / benzene / 20 h / 55 °C

2: 80 percent / Et₃N / ethanol; benzene / 20 h / Heating

3: 87 percent / Pyrrolidine / AcOH / benzene / 5 h / Heating

4: 95 percent / KOH / ethanol / 24 h / Heating

With pyrrolidine; potassium hydroxide; sodium hydride; acetic acid; triethylamine; In ethanol; benzene;
DOI:10.1016/S0040-4039(01)90406-X