4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

Base Information

Chemical Name:4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine
CAS No.:209807-98-7
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

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Chemical Property of 4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

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Technology Process of 4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

There total 4 articles about 4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 77350-52-8
N,N-diethyl-4-iodobenzamide

: 139290-70-3
tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 209807-98-7
4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

Guidance literature:: N,N-diethyl-4-iodobenzamide; With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jm000229p

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 209807-98-7
4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 7.67 g / Na₂CO₃ / tetrahydrofuran; H₂O / 1 h / Heating

2.1: 98 percent / iPrMgCl / tetrahydrofuran / 1 h / -5 °C

3.1: t-BuLi; N,N,N',N'-tetramethylenediamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 28 percent / tetrahydrofuran / -78 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; isopropylmagnesium chloride; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1021/jm000229p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 209807-98-7
4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 7.67 g / Na₂CO₃ / tetrahydrofuran; H₂O / 1 h / Heating

2.1: 98 percent / iPrMgCl / tetrahydrofuran / 1 h / -5 °C

3.1: t-BuLi; N,N,N',N'-tetramethylenediamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 28 percent / tetrahydrofuran / -78 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; isopropylmagnesium chloride; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1021/jm000229p