77350-52-8

Usage

Uses

Used in Organic Synthesis:
N,N-diethyl-4-iodobenzamide is used as a reagent in organic synthesis for the preparation of various pharmaceutical and agrochemical products. Its unique structure and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Dye Manufacturing:
N,N-diethyl-4-iodobenzamide is also used as an intermediate in the manufacturing of dyes and other organic compounds. Its presence in these compounds contributes to the development of new dyes with improved properties and applications.
Used in Pharmaceutical Industry:
N,N-diethyl-4-iodobenzamide is used as a key intermediate in the synthesis of various pharmaceutical products. Its reactivity and structural features enable the development of new drugs with enhanced therapeutic effects and reduced side effects.
Used in Agrochemical Industry:
N,N-diethyl-4-iodobenzamide is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its involvement in the synthesis of these compounds helps in the development of more effective and environmentally friendly agrochemicals.

Upstream product

• 109-89-7 diethylamine 
• 1711-02-0 4-iodobenzoic acid chloride 
• 619-58-9 4-iodobenzoic acid 

Downstream Products

• 130447-17-5 N,N-diethyl-4-(thiophen-2-yl)benzamide 
• 308110-26-1 N,N-diethyl-4-[hydroxy(5-isoquinolinyl)methyl]benzamide 
• 308110-38-5 N,N-diethyl-4-(hydroxy-quinolin-7-yl-methyl)-benzamide 
• 308110-39-6 N,N-diethyl-4-(hydroxy-quinolin-6-yl-methyl)-benzamide 
• 308110-32-9 4-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)(hydroxy)methyl]-N,N-diethylbenzamide 
• 209807-98-7 4-(4'-N',N'-diethylaminocarbonylbenzoyl)-N-tert-butoxycarbonylpiperidine 
• 308110-29-4 N,N-diethyl-4-[hydroxy[1-(phenylsulfonyl)-1H-indol-6-yl]methyl]benzamide 
• 193217-40-2 4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)benzyl)-N,N-diethylbenzamide 
• 209808-08-2 4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)-4-chlororobenzyl)-N,N-diethylbenzamide 
• 390366-08-2 4,4'-bis[(4-(N,N-diethylcarboxamido)phenyl)ethynyl]-2,2'-bipyridinyl 
• 390366-28-6 5,5'-bis[(4-(N,N-diethylcarboxamido)phenyl)ethynyl]-2,2'-bipyridinyl 
• 1696-17-9 N,N-diethylbenzamide 
• 691877-61-9 4-[hydroxy(3-nitrophenyl)methyl]-N,N-diethylbenzamide 
• 691358-47-1 3-[[4-[(diethylamino)carbonyl]phenyl]hydroxymethyl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Butenolide synthesis from functionalized cyclopropenones

A general method to synthesize substituted butenolides from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediates can be trapped by pendant hydroxy groups to afford target butenolide scaffolds. The reaction proceeds efficiently in diverse solvents and with low catalyst loadings. Importantly, the cyclization is tolerant of a broad range of functional groups, yielding a variety of α- and γ-substituted butenolides.

Palladium-Catalyzed Alkoxycarbonylation of Unactivated Secondary Alkyl Bromides at Low Pressure

Catalytic carbonylations of organohalides are important C-C bond formations in chemical synthesis. Carbonylations of unactivated alkyl halides remain a challenge and currently require the use of alkyl iodides under harsh conditions and high pressures of CO. Herein we report a palladium-catalyzed alkoxycarbonylation of secondary alkyl bromides that proceeds at low pressure (2 atm CO) under mild conditions. Preliminary mechanistic studies are consistent with a hybrid organometallic-radical process. These reactions efficiently deliver esters from unactivated alkyl bromides across a diverse range of substrates and represent the first catalytic carbonylations of alkyl bromides with carbon monoxide.

SOLID FORMS OF 4-{(R)-(3-AMINOPHENYL)[4-(4-FLUOROBENZYL)-PIPERAZIN-1-YL]METHYL}-N,N-DIETHYLBENZAMIDE, COMPOSITIONS THEREOF, AND USES THEREWITH

Solid forms comprising salts of 4-{(R)-(3-aminophenyl)[4-(4-fluorobenzyl)piperazin-1- yl]methyl}-N,N-diethylbenzamide, compositions comprising the solid forms, methods of making the solid forms, and methods of their use for the treatment of various diseas

Method Of Treating Anxious Major Depressive Disorder

The invention is directed to using 4-{(3-aminophenyl)[4-(4-fluorobenzyl)piperazin-1-yl]methyl}-N,N-diethylbenzamide, or enantiomer thereof, or pharmaceutically acceptable salt thereof, and/or mixture thereof to treat anxious major depressive disorder (AMD

Selective angiotensin II AT2 receptor agonists: Benzamide structure-activity relationships

In the investigation of the structure-activity relationship of nonpeptide AT2 receptor agonists, a series of substituted benzamide analogues of the selective nonpeptide AT2 receptor agonist M024 have been synthesised. In a second ser

DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF

Compounds of formula: (chemical formula to be inserted here - please see paper copy) wherein R1 and R2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They ar

DIARYLMETHYL PIPERAZINE DERIVATIVES,REPARATIONS THEREOF AND USES THEREOF

Compounds of general formula as well as salts,enantiomers thereof and pharmaceutical compositions including the compounds are prepared.They are useful in therapy,in particular in the management of pain, depression and anxiety

DIARYLMETHYL PIPERAZINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF

Compounds of formula: wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in pa

4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS

Compounds of general formula:[Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositio

4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS

Compounds of general formula: wherein R1 and R2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particula