2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

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Chemical Name:2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate
CAS No.:944088-78-2
Molecular Formula:C₁₉H₂₇BrN₄O₁₀S
Molecular Weight:583.414
Hs Code.:

Synonyms:2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

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Chemical Property of 2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

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Technology Process of 2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

There total 2 articles about 2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

: 944088-70-4
2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 7143-01-3
Methanesulfonic anhydride

: 944088-78-2
2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

Guidance literature:: 2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide; Methanesulfonic anhydride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 1.58333h;

With potassium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 680199-30-8
2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

: 944088-78-2
2-[N-(2-bromoethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / LiBr / various solvent(s) / cooling

2: 95 percent / pyridine / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; lithium bromide; In dichloromethane;
DOI:10.1016/j.tet.2007.04.044