2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

Base Information

Chemical Name:2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester
CAS No.:254893-21-5
Molecular Formula:C₂₁H₃₂N₂O₃
Molecular Weight:360.497
Hs Code.:

Synonyms:2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

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Chemical Property of 2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

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Technology Process of 2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

There total 3 articles about 2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 137650-02-3,85387-43-5
(1-benzylpiperidin-2-yl)methanol

: 146176-60-5
2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride

: 254893-21-5
2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

Guidance literature:: (1-benzylpiperidin-2-yl)methanol; With sodium hydride; In tetrahydrofuran; for 0.5h; Heating;

2,2,4,4-tetramethyl-1,3-oxazolidine-3-carbonyl chloride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1055/s-1999-3612

Reference yield:

: 100-39-0
benzyl bromide

: 254893-21-5
2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / K₂CO₃ / toluene / 16 h / Heating

2.1: NaH / tetrahydrofuran / 0.5 h / Heating

2.2: 93 percent / tetrahydrofuran / 2 h / Heating

With sodium hydride; potassium carbonate; In tetrahydrofuran; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1055/s-1999-3612

Reference yield:

: 3433-37-2
piperidin-2-ylmethanol

: 254893-21-5
2,2,4,4-tetramethyl-oxazolidine-3-carboxylic acid 1-benzyl-piperidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / K₂CO₃ / toluene / 16 h / Heating

2.1: NaH / tetrahydrofuran / 0.5 h / Heating

2.2: 93 percent / tetrahydrofuran / 2 h / Heating

With sodium hydride; potassium carbonate; In tetrahydrofuran; toluene; 1.1: Alkylation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1055/s-1999-3612