4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

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Chemical Name:4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate
CAS No.:1224949-19-2
Molecular Formula:C₂₅H₂₉N₃O₄
Molecular Weight:435.523
Hs Code.:

Synonyms:4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

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Chemical Property of 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

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Technology Process of 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

There total 9 articles about 4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1224950-15-5
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-benzyloxycarbonylaminoacetate

: 1224949-19-2
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 14h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1224949-19-2
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -76 °C

1.2: 2 h / -74 °C

2.1: potassium carbonate; methanol / 2 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.92 h / -72 °C

3.2: 0.58 h / -72 °C

4.1: manganese(IV) oxide / dichloromethane / 15 h / 20 °C

5.1: triethylamine / ethanol / 0.5 h / 20 °C

5.2: 15 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

6.2: 0 °C

7.1: sodium tetrahydroborate; methanol / 2 h / 20 °C

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

With hydrogenchloride; methanol; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;

Reference yield:

: 1224949-51-2
8-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-1,4-dioxaspiro[4.5]decan-8-ol

: 1224949-19-2
4-hydroxy-4-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-cis-cyclohexyl 2-aminoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

1.2: 0 °C

2.1: sodium tetrahydroborate; methanol / 2 h / 20 °C

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;