Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

Base Information

Chemical Name:Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester
CAS No.:516473-47-5
Molecular Formula:C₃₈H₃₄N₆O₈S₂
Molecular Weight:766.855
Hs Code.:

Synonyms:Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

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Chemical Property of Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

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Technology Process of Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

There total 5 articles about Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84468-15-5
5-isoquinolinesulfonyl chloride

: Isoquinoline-5-sulfonic acid 4-{(S)-2-methylamino-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

: 516473-47-5
Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm021049d

Reference yield:

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 516473-47-5
Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 79 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

3.1: TFA / CH₂Cl₂ / 3 h / 20 °C

4.1: Et₃N / CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d

Reference yield:

: 82038-34-4
(S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-hydroxyphenyl)propanoic acid

: 516473-47-5
Isoquinoline-5-sulfonic acid 4-{(S)-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-[4-(4-nitro-phenyl)-piperazin-1-yl]-3-oxo-propyl}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 79 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

3.1: TFA / CH₂Cl₂ / 3 h / 20 °C

4.1: Et₃N / CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d