1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Base Information

Chemical Name:1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine
CAS No.:516472-90-5
Molecular Formula:C₂₅H₃₂N₄O₆
Molecular Weight:484.552
Hs Code.:

Synonyms:1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

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Chemical Property of 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

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Technology Process of 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

There total 1 articles about 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 82038-34-4
(S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-hydroxyphenyl)propanoic acid

: 516472-90-5
1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm021049d

Reference yield: 79.0%

: 84468-15-5
5-isoquinolinesulfonyl chloride

: 516472-90-5
1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

: 516473-18-0
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine; With sodium hydride; In tetrahydrofuran; for 0.166667h;

5-isoquinolinesulfonyl chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm021049d

Reference yield:

: 516472-90-5
1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

: Isoquinoline-5-sulfonic acid 4-{(S)-3-[4-(4-amino-phenyl)-piperazin-1-yl]-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-oxo-propyl}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 0.17 h

1.2: 79 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

2.1: TFA / CH₂Cl₂ / 3 h / 20 °C

3.1: Et₃N / CH₂Cl₂ / 18 h / 20 °C

4.1: H₂ / Pd/C / methanol / 4 h

With hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm021049d