3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Base Information

Chemical Name:3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide
CAS No.:1095005-92-7
Molecular Formula:C₂₆H₂₉ClN₄O₃
Molecular Weight:480.994
Hs Code.:

Synonyms:3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

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Chemical Property of 3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

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Technology Process of 3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

There total 9 articles about 3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095003-49-8
N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

: 107-04-0
1-Bromo-2-chloroethane

: 1095005-92-7
3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 83 ℃; for 16h;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095005-92-7
3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 120 °C / Microwave irradiation

3: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

4: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 60 - 100 °C / Microwave irradiation

5: potassium carbonate / acetonitrile / 16 h / 83 °C

With ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095005-92-7
3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 120 °C / Microwave irradiation

2: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

3: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 60 - 100 °C / Microwave irradiation

4: potassium carbonate / acetonitrile / 16 h / 83 °C

With ammonium formate; potassium carbonate; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; acetonitrile;