N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide
CAS No.:1095003-49-8
Molecular Formula:C₂₄H₂₆N₄O₃
Molecular Weight:418.495
Hs Code.:

Synonyms:N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

There total 8 articles about N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1095005-66-5
2-(2-(benzyloxy)phenyl)propan-2-amine

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 765-30-0
Cyclopropylamine

: 1095003-49-8
N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: 2-(2-(benzyloxy)phenyl)propan-2-amine; methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 120 ℃; for 1.66667h; Microwave irradiation;

Cyclopropylamine; With cyclopentylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

With palladium 10% on activated carbon; ammonium formate; In ethanol; at 60 - 100 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.bmcl.2020.127412

Reference yield:

: C₂₄H₂₅BrN₄O₃

: 1095003-49-8
N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; at 60 - 100 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1095005-58-5
methyl 3-[(cyanomethyl)amino]-4-methylbenzoate

: 1095003-49-8
N-cyclopropyl-3-(3-(2-(2-hydroxyphenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-dichloro-benzene / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 120 °C / Microwave irradiation

3: cyclopentylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

4: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 60 - 100 °C / Microwave irradiation

With ammonium formate; N-ethyl-N,N-diisopropylamine; cyclopentylmagnesium bromide; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; 1,2-dichloro-benzene;