Technology Process of 5-(3-(6-morpholinopyridin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine
There total 10 articles about 5-(3-(6-morpholinopyridin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(4-methoxybenzyl)-5-(3-(6-morpholinopyridin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine;
With
trifluoroacetic acid;
In
chloroform;
at 80 ℃;
for 12h;
With
water; sodium hydrogencarbonate;
pH=8;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1.25 h / 65 - 80 °C
2.1: hydrazine / ethanol / 12 h / Reflux
3.1: ethanol / 2 h / Reflux
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux
5.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C
7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere
8.1: 5 h / 130 °C / Sealed tube
9.1: trifluoroacetic acid / chloroform / 12 h / 80 °C
9.2: pH 8 / Cooling with ice
With
potassium phosphate; iodine; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; hydrazine;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; chloroform; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrazine / ethanol / 12 h / Reflux
2.1: ethanol / 2 h / Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / toluene / 12 h / Reflux
4.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -25 °C
6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere
7.1: 5 h / 130 °C / Sealed tube
8.1: trifluoroacetic acid / chloroform / 12 h / 80 °C
8.2: pH 8 / Cooling with ice
With
potassium phosphate; iodine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; hydrazine;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; chloroform; N,N-dimethyl-formamide; toluene; mineral oil;
