N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Base Information

Chemical Name:N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
CAS No.:1320288-48-9
Molecular Formula:C₃₄H₅₅N₇O₂
Molecular Weight:593.856
Hs Code.:

Synonyms:N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

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Chemical Property of N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

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Technology Process of N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

There total 9 articles about N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4318-37-0
1-Methylhomopiperazine

: C₂₈H₄₂ClN₅O₂

: 1320288-48-9
N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Guidance literature:: With trifluoroacetic acid; In isopropyl alcohol; at 160 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm200903z

Reference yield:

: 927173-22-6
methyl 5-methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzoate

: 1320288-48-9
N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium acetate; water; iron / ethyl acetate / Reflux

2: acetic acid / water / 20 °C

3: water; sodium hydroxide / methanol / 3 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / 7 h / Reflux

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

6: trifluoroacetic acid / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With ammonium acetate; water; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm200903z

Reference yield:

: 574738-68-4
methyl 2-amino-5-methoxy-4-(3-(piperidin-1-yl)propoxy)benzoate

: 1320288-48-9
N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / water / 20 °C

2: water; sodium hydroxide / methanol / 3 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / 7 h / Reflux

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

5: trifluoroacetic acid / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With water; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; water; isopropyl alcohol;
DOI:10.1021/jm200903z