Technology Process of benzyl 3,4-di-O-benzyl-D-glucuronal
There total 6 articles about benzyl 3,4-di-O-benzyl-D-glucuronal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,4-di-O-benzyl-D-glucal;
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; water;
In
dichloromethane;
at 0 ℃;
for 4h;
Inert atmosphere;
With
potassium hydrogencarbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.joc.0c00510
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
2.2: 0 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C
4.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane; water / 1 h / 20 °C
5.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 10 h
With
1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; sodium hydride; potassium hydrogencarbonate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2013.01.007
