(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Base Information

Chemical Name:(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate
CAS No.:1596272-61-5
Molecular Formula:C₃₅H₃₁Cl₂N₅O₃
Molecular Weight:640.569
Hs Code.:

Synonyms:(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Suppliers and Price of (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

There total 8 articles about (E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 5407-57-8
N-(7-chloroquinolin-4-yl)ethylenediamine

: 1596272-35-3
(E)-methyl 3-(4-(2-(3-(4-chlorophenyl)thioureido)phenoxy)phenyl)-2-methylacrylate

: 1596272-61-5
(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1596272-61-5
(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 0.33 h / 20 °C

2.2: 255 / 72 h / 20 °C

3.1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: sodium tetrahydroborate / methanol / 0.83 h / 0 - 20 °C

5.1: iron; acetic acid / 0.33 h / 90 °C

6.1: N,N-dimethyl-formamide / 20 °C

7.1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; sodium tetrahydroborate; iron; potassium carbonate; acetic acid; triethylamine; mercury dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Morita-Baylis-Hillman Alkylation / 2.2: |Morita-Baylis-Hillman Alkylation;
DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1596272-61-5
(E)-methyl 3-(4-(2-((E)-2-(4-chlorophenyl)-3-(2-(7-chloroquinolin-4-ylamino)ethyl)guanidino)phenoxy)phenyl)-2-methylacrylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 0.33 h / 20 °C

2.2: 255 / 72 h / 20 °C

3.1: pyridine / dichloromethane / 0.5 h / 0 - 20 °C

4.1: sodium tetrahydroborate / methanol / 0.83 h / 0 - 20 °C

5.1: iron; acetic acid / 0.33 h / 90 °C

6.1: N,N-dimethyl-formamide / 20 °C

7.1: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; sodium tetrahydroborate; iron; potassium carbonate; acetic acid; triethylamine; mercury dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Morita-Baylis-Hillman Alkylation / 2.2: |Morita-Baylis-Hillman Alkylation;
DOI:10.1016/j.bmcl.2014.02.044