4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE

Base Information

• Chemical Name: 4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE
• CAS No.: 5407-57-8
• Molecular Formula: C11H12 Cl N3
• Molecular Weight: 221.689
• Hs Code.: 2933499090
• Mol file: 5407-57-8.mol

Synonyms:1,2-Ethanediamine,N-(7-chloro-4-quinolinyl)- (9CI); Quinoline, 4-[(2-aminoethyl)amino]-7-chloro-(6CI,8CI); N-(7-Chloro-4-quinolinyl)-1,2-ethanediamine; NSC 5447; WR 36001

Chemical Property of 4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE

Chemical Property:

• Boiling Point: 415°Cat760mmHg
• Flash Point: 204.8°C
• PSA: 50.94000
• Density: 1.316g/cm³
• LogP: 3.03210
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

N1-(7-Chloro-4-quinolinyl)-1,2-ethanediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE

There total 8 articles about 4-(2-AMINOETHYL)AMINO-7-CHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + ethylenediamine (107-15-3,85404-18-8) → N-(7-chloroquinolin-4-yl)ethylenediamine (5407-57-8)

Guidance literature:

at 80 - 140 ℃; for 13h;

DOI:10.1016/j.bmcl.2007.06.070

Reference yield: 65.0%

[2-(7-chloroquinolin-4-ylamino)ethyl]carbamic acid tert-butyl ester (849180-03-6) → N-(7-chloroquinolin-4-yl)ethylenediamine (5407-57-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jm800737y

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) + ethylenediamine (107-15-3,85404-18-8) → N-(7-chloroquinolin-4-yl)ethylenediamine (5407-57-8) + N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine (140926-75-6)

Guidance literature:

With phenol;

upstream raw materials:

4,7-dichloroquinoline

ethylenediamine

7-chloro-4-hydroxylquinoline

4-hydroxy-7-chloro-3-quinoline-carboxylic acid

Downstream raw materials:

1-[2-(7-chloroquinolin-4-ylamino)ethyl]carbamic acid phenyl ester

N¹-(7-chloroquinolin-4-yl)-N²-{2-[(dimethylamino)methyl]benzyl}ethan-1,2-diamine

N₁,N₁-dibenzyl-N₃-(2-(7-chloroquinolin-4-ylamino)ethyl)propane-1,3-diamine

N₁,N₁-dibenzyl-N₂-(2-(7-chloroquinolin-4-ylamino)ethyl)ethane-1,2-diamine