2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Base Information

Chemical Name:2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol
CAS No.:192767-02-5
Molecular Formula:C₂₄H₁₅Cl₂F₁₀NO₃
Molecular Weight:626.278
Hs Code.:

Synonyms:2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

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Chemical Property of 2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

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Technology Process of 2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

There total 10 articles about 2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192767-16-1
4-(2-(3,4-bis-difluoromethoxy-phenyl)-2-{4-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-phenyl}-ethyl)-3,5-dichloro-pyridine

: 192767-02-5
2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(02)00349-9

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 192767-02-5
2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / diethyl ether / -78 °C

1.2: diethyl ether

2.1: i-Pr₂NEt / CH₂Cl₂

3.1: Mg / tetrahydrofuran

3.2: tetrahydrofuran

4.1: SOCl₂; i-Pr₂NEt / toluene

5.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -30 - 25 °C

6.1: NaOH / ethanol; tetrahydrofuran / 60 °C

6.2: aq. HCl

7.1: TBAF / tetrahydrofuran

With sodium hydroxide; n-butyllithium; thionyl chloride; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(02)00349-9

Reference yield:

: 2402-72-4
2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 192767-02-5
2-{4-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(3,5-dichloro-pyridin-4-yl)-ethyl]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: i-Pr₂NEt / CH₂Cl₂

2.1: Mg / tetrahydrofuran

2.2: tetrahydrofuran

3.1: SOCl₂; i-Pr₂NEt / toluene

4.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -30 - 25 °C

5.1: NaOH / ethanol; tetrahydrofuran / 60 °C

5.2: aq. HCl

6.1: TBAF / tetrahydrofuran

With sodium hydroxide; thionyl chloride; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(02)00349-9