(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Base Information

Chemical Name:(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester
CAS No.:1613621-71-8
Molecular Formula:C₂₆H₂₂F₃N₅O₄
Molecular Weight:525.487
Hs Code.:

(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Synonyms:(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

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Chemical Property of (R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

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Technology Process of (R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

There total 16 articles about (R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 627-27-0
homoalylic alcohol

: 1613621-60-5
(S)-5-(2-bromo-4-cyanophenyl)-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4] triazolo[4,3-a] pyrimidine-6-carboxylic acid methyl ester

: 1613621-71-8
(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

: 1613621-90-1
C₂₆H₂₂F₃N₅O₄

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylmethylamine; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 95 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1736-70-5
3-trifluoromethylphenylthiourea

: 1613621-71-8
(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Tris(trimethylsilyl) phosphate / tetrahydrofuran / 17 h / 75 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2.33 h / 10 - 20 °C / Inert atmosphere; Cooling with ice

3.1: daicel chiralpak IC colunm (5 μm, 250 mmx10 mm)

4.1: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylmethylamine / N,N-dimethyl-formamide / 18 h / 95 °C / Inert atmosphere

With 2,6-dimethylpyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Tris(trimethylsilyl) phosphate; dicyclohexylmethylamine; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1613621-56-9
4-(2-bromo-4-cyanophenyl)-6-methyl-2-thioxo-1-(3-trifluoromethylphenyl)-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

: 1613621-71-8
(R)-5-[2-(4-hydroxy-buten-1-yl)-4-cyano-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 2.33 h / 10 - 20 °C / Inert atmosphere; Cooling with ice

2.1: daicel chiralpak IC colunm (5 μm, 250 mmx10 mm)

3.1: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylmethylamine / N,N-dimethyl-formamide / 18 h / 95 °C / Inert atmosphere

With 2,6-dimethylpyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylmethylamine; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; N,N-dimethyl-formamide;