penta-N-Boc-argiotoxin-636

Base Information

• Chemical Name: penta-N-Boc-argiotoxin-636
• CAS No.: 151255-93-5
• Molecular Formula: C₅₄H₉₂N₁₀O₁₆
• Molecular Weight: 1137.38
• Mol file: 151255-93-5.mol

Synonyms:penta-N-Boc-argiotoxin-636

Chemical Property of penta-N-Boc-argiotoxin-636

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of penta-N-Boc-argiotoxin-636

There total 16 articles about penta-N-Boc-argiotoxin-636 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-O-benzyl-penta-N-Boc-argiotoxin-636 (151255-92-4) → penta-N-Boc-argiotoxin-636 (151255-93-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)87944-8

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → penta-N-Boc-argiotoxin-636 (151255-93-5)

Guidance literature:

Multi-step reaction with 11 steps

1: 95 percent / methanol / 24 h / Ambient temperature

2: 75 percent / LiAlH₄ / diethyl ether / 3 h / 0 °C

3: 89 percent / methanol / 20 h / Ambient temperature

4: 98 percent / methanol / 20 h / Ambient temperature

5: 74 percent / LiAlH₄ / diethyl ether / 3 h / 0 °C

6: 85 percent / dimethylformamide

7: 91 percent / H₂ / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

8: 88 percent / dimethylformamide / Ambient temperature

9: 89 percent / H₂ / 10percent Pd-C / methanol / Ambient temperature

10: 94 percent / DMAP / dimethylformamide / Ambient temperature

11: 95 percent / H₂ / 10percent Pd-C / methanol / Ambient temperature

With dmap; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)87944-8

Reference yield:

2,4-bis(benzyloxy)acetophenone (22877-01-6) → penta-N-Boc-argiotoxin-636 (151255-93-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / Tl(NO₃)3*3H₂O, 70percent HClO₄ / 1.33 h / Ambient temperature

2: 98 percent / LiOH*H₂O / methanol; H₂O / Ambient temperature

3: 86 percent / dicyclohexylcarbodiimide (DCC) / acetone; ethyl acetate / 1) 0 deg C, 12 h, 2) slowly to r.t.

4: 94 percent / DMAP / dimethylformamide / Ambient temperature

5: 95 percent / H₂ / 10percent Pd-C / methanol / Ambient temperature

With dmap; lithium hydroxide; perchloric acid; hydrogen; dicyclohexyl-carbodiimide; thallium(III) nitrate; palladium on activated charcoal; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4020(01)87944-8

upstream raw materials:

di-O-benzyl-penta-N-Boc-argiotoxin-636

di-tert-butyl dicarbonate

2,4-bis(benzyloxy)acetophenone

2-(2,4-bis(benzyloxy)phenyl)acetic acid

Refernces