1-(2,4-bis(benzyloxy)phenyl)ethanone

Base Information

• Chemical Name: 1-(2,4-bis(benzyloxy)phenyl)ethanone
• CAS No.: 22877-01-6
• Molecular Formula: C22H20 O3
• Molecular Weight: 332.399
• Mol file: 22877-01-6.mol

Synonyms:Acetophenone,2',4'-bis(benzyloxy)- (7CI,8CI); 1-[2,4-Bis(benzyloxy)phenyl]ethanone;2',4'-Bis(benzyloxy)acetophenone; 2',4'-Dibenzyloxyacetophenone;Di-O-benzylresacetophenone; NSC 263763

Chemical Property of 1-(2,4-bis(benzyloxy)phenyl)ethanone

Chemical Property:

• Vapor Pressure: 1.41E-10mmHg at 25°C
• Melting Point: 81 - 83°C
• Boiling Point: 511.5°Cat760mmHg
• Flash Point: 255.5°C
• PSA: 35.53000
• Density: 1.144g/cm³
• LogP: 5.04720
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1-(2,4-Bis(benzyloxy)phenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,4-bis(benzyloxy)phenyl)ethanone

There total 6 articles about 1-(2,4-bis(benzyloxy)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + benzyl bromide (100-39-0) → 2,4-bis(benzyloxy)acetophenone (22877-01-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 48h; Heating / reflux;

Reference yield: 94.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) + benzyl chloride (100-44-7) → 2,4-bis(benzyloxy)acetophenone (22877-01-6)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; potassium iodide; In acetone; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/ol901022g

Reference yield: 85.0%

2-hydroxy-1-(4-hydroxyphenyl)ethan-1-one (5706-85-4) + benzyl bromide (100-39-0) → 2,4-bis(benzyloxy)acetophenone (22877-01-6)

Guidance literature:

With potassium phosphate; tetrabutylammomium bromide; In water; at 20 ℃; Large scale;

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

benzyl tosylate

benzyl bromide

benzyl chloride

Downstream raw materials:

2',3,4,4'-tetrakis(benzyloxy)chalcone

2,2',4'-tribenzyloxy-4-methoxy-trans-chalcone

(E)-1-(2,4-Bis-benzyloxy-phenyl)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-propenone

2,4-Dibenzyloxyphenyl-acetat

Refernces

• 1、 Li, Qi,Mo, Jun,Xiong, Baichen,Liao, Qinghong,Chen, Ying,Wang, Yuanyuan,Xing, Shuaishuai,He, Siyu,Lyu, Weiping,Zhang, Ning,Sun, Haopeng. "Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson’s Disease". . p. 81 - 96. Retrieved 2021/12/17.
• 2、 -. "RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE". Page/Page column 20. . Retrieved 2019/04/26.