1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

Base Information

Chemical Name:1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol
CAS No.:1264755-22-7
Molecular Formula:C₁₇H₁₉ClF₃N₃O₃S
Molecular Weight:437.87
Hs Code.:

Synonyms:1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

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Chemical Property of 1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

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Technology Process of 1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

There total 4 articles about 1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400797-90-2
5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 1264755-22-7
1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

Guidance literature:: 5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; (R)-(-)-epichlorohydrin; ytterbium(III) trifluoromethanesulfonate hydrate; In toluene; at 60 - 61 ℃;

With hydrogenchloride; water; In 2-methyltetrahydrofuran; toluene; at 65 - 67 ℃;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1264755-22-7
1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / acetonitrile / 65 °C / Industry scale

2.1: 4-methylpiperidin; toluene-4-sulfonic acid / toluene / Reflux

2.2: -20 - 20 °C

3.1: hydrazine hydrochloride; sodium hydroxide / ethanol; water / 1.33 h

3.2: 6.75 h / 20 °C / Reflux

4.1: ytterbium(III) trifluoromethanesulfonate hydrate / toluene / 60 - 61 °C

4.2: 65 - 67 °C

With 4-methylpiperidin; hydrazine hydrochloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; sodium hydroxide; ytterbium(III) trifluoromethanesulfonate hydrate; In ethanol; water; toluene; acetonitrile;

Reference yield:

: 1264755-13-6
1-methanesulfonyl-3-(4-trifluoromethyl-benzoyl)-piperidin-4-one

: 1264755-22-7
1-chloro-3-[5-methanesulfonyl-3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propan-2(R)-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrochloride; sodium hydroxide / ethanol; water / 1.33 h

1.2: 6.75 h / 20 °C / Reflux

2.1: ytterbium(III) trifluoromethanesulfonate hydrate / toluene / 60 - 61 °C

2.2: 65 - 67 °C

With hydrazine hydrochloride; sodium hydroxide; ytterbium(III) trifluoromethanesulfonate hydrate; In ethanol; water; toluene;