5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Base Information

Chemical Name:5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
CAS No.:400797-90-2
Molecular Formula:C14H14F3N3O2S
Molecular Weight:345.345
Hs Code.:
Mol file:400797-90-2.mol

Synonyms:5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Suppliers and Price of 5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

There total 6 articles about 5-Methanesulfonyl-3-(4-trifluoroMethyl-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 218780-53-1
1-(methylsulfonyl)piperidin-4-one

: 400797-90-2
5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: 4-Trifluoromethylbenzaldehyde; 1-(methylsulfonyl)piperidin-4-one; With hydrazine hydrochloride; In methanol; at 55 ℃; Inert atmosphere;

With bromine; In methanol; at 0 - 10 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0036-1591941

Reference yield: 75.0%

: 5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine hydrochloride

: 400797-90-2
5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: With oxygen; copper diacetate; In dimethyl sulfoxide; at 85 ℃; under 760.051 Torr;
DOI:10.1055/s-0036-1591941

Reference yield:

: 1264755-13-6
1-methanesulfonyl-3-(4-trifluoromethyl-benzoyl)-piperidin-4-one

: 400797-90-2
5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: 1-methanesulfonyl-3-(4-trifluoromethyl-benzoyl)-piperidin-4-one; With hydrazine hydrochloride; sodium hydroxide; In ethanol; water; for 1.33333h;

In tert-butyl methyl ether; at 20 ℃; for 6.75h; Product distribution / selectivity; Reflux;