4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

Base Information

Chemical Name:4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane
CAS No.:1268830-15-4
Molecular Formula:C₂₈H₃₃N₅O₂
Molecular Weight:471.602
Hs Code.:

Synonyms:4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

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Chemical Property of 4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

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Technology Process of 4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

There total 5 articles about 4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 220898-23-7
1-tert-butoxycarbonyl-7-phenyl-1,4-diazepane

: 186202-42-6
4-{[5-(chloromethyl)-1H-imidazol-1-yl]methyl}benzonitrile

: 1268830-15-4
4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 4h;
DOI:10.1021/jm101067y

Reference yield:

: 220898-16-8
1-tert-butoxycarbonyl-7-phenyl-1,4-diazepan-5-one

: 1268830-15-4
4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm101067y

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 1268830-15-4
4-tert-butoxycarbonyl-1-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-5-phenyl-1,4-diazepane

Guidance literature:: Multi-step reaction with 5 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 8 h / 135 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 60 °C / 37503.8 Torr / Autoclave

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; water / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 80 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; acetonitrile;
DOI:10.1021/jm101067y