4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile

Base Information

• Chemical Name: 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile
• CAS No.: 927822-41-1
• Molecular Formula: C₁₆H₁₆N₆O₂
• Molecular Weight: 324.342
• Mol file: 927822-41-1.mol

Synonyms:4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile

Chemical Property of 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile

There total 6 articles about 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-((6-amino-2-chloro-9H-purin-9-yl)methyl)benzonitrile (927822-40-0) + 2-methoxy-ethanol (109-86-4,95507-80-5) → 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile (927822-41-1)

Guidance literature:

With sodium; at 120 ℃; for 17h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00960

Reference yield:

4-((2,6-dichloro-9H-purin-9-yl)methyl)benzonitrile (115204-76-7) → 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile (927822-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / N,N-dimethyl-formamide; methanol / 14 h / 20 °C

2: sodium / 6 h / 100 °C / Inert atmosphere

With ammonia; sodium; In methanol; N,N-dimethyl-formamide;

Reference yield:

4-cyanobenzyl bromide (17201-43-3) → 4-((6-amino-2-(2-methoxyethoxy )-9H-purin-9-yl)methyl)benzonitrile (927822-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl acetamide / 3 h / 85 - 90 °C

2: ammonia / N,N-dimethyl-formamide; methanol / 14 h / 20 °C

3: sodium / 6 h / 100 °C / Inert atmosphere

With ammonia; sodium; potassium carbonate; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

4-((6-amino-2-chloro-9H-purin-9-yl)methyl)benzonitrile

2-methoxy-ethanol

sodium 2-methoxyethanolate

4-cyanobenzyl bromide

Downstream raw materials:

4-((6-amino-8-bromo-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzonitrile