(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Base Information

Chemical Name:(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate
CAS No.:173935-34-7
Molecular Formula:C₃₀H₃₇N₃O₃
Molecular Weight:487.642
Hs Code.:

Synonyms:(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Suppliers and Price of (1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

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Chemical Property of (1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Chemical Property:

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Technology Process of (1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

There total 8 articles about (1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2216-51-5
(-)-menthol

: 173935-34-7
(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH*H₂O / 6 h / 110 °C

2: dimethylformamide / 0.5 h / 130 °C

3: 20percent aq. TiCl₃ / acetone

4: 1.) pyridinium hydrochloride / 1.) DMF, RT, 30 min, 2.) DMF, 110 deg C, 2 h

With titanium(III) chloride; pyridine hydrochloride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm950197j

Reference yield:

: 52241-04-0
(+/-)-4-(4-bromophenyl)-3-methyl-4-oxobutyric acid

: 173935-34-7
(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Guidance literature:: Multi-step reaction with 6 steps

2: 68 percent / fuming HNO₃ / 0.25 h

3: p-TsOH*H₂O / 6 h / 110 °C

4: dimethylformamide / 0.5 h / 130 °C

5: 20percent aq. TiCl₃ / acetone

6: 1.) pyridinium hydrochloride / 1.) DMF, RT, 30 min, 2.) DMF, 110 deg C, 2 h

With titanium(III) chloride; nitric acid; pyridine hydrochloride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm950197j

Reference yield:

: (R)-(-)-4-(4-bromophenyl)-3-methyl-4-oxobutyric acid

: 173935-34-7
(1R,2S,5R)-menthyl (R)-(4-(4-benzylamino)-7-quinazolinyl)-3-methyl-4-oxobutyrate

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / fuming HNO₃ / 0.25 h

2: p-TsOH*H₂O / 6 h / 110 °C

3: dimethylformamide / 0.5 h / 130 °C

4: 20percent aq. TiCl₃ / acetone

5: 1.) pyridinium hydrochloride / 1.) DMF, RT, 30 min, 2.) DMF, 110 deg C, 2 h

With titanium(III) chloride; nitric acid; pyridine hydrochloride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm950197j