4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

Base Information Edit

Chemical Name:4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
CAS No.:120280-13-9
Molecular Formula:C₁₀H₁₆N₂O₄S₃
Molecular Weight:324.446
Hs Code.:
European Community (EC) Number:601-695-9
DSSTox Substance ID:DTXSID10274396,DTXSID70861261
Nikkaji Number:J1.325.464H
ChEMBL ID:CHEMBL269001
Mol file:120280-13-9.mol

Synonyms:120280-13-9;DORZOLAMIDE BASE;4-(ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide;4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide;CHEMBL269001;(4-Ethylamino)-5,6-dihydro-6-methyl-4H-thieno(2,3B)thiopyran-2-sulphonamide-7,7-dioxide;trans-6-Methyl-4-ethylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide;4H-Thieno[2,3-b]thiopyran-2-sulfonamide,4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4R-cis)-;(4R,?6R)?-Dorzolamide;SCHEMBL3306381;DTXSID10274396;DTXSID70861261;HMS3745I07;HMS3868E03;BDBM50043906;AKOS015914563;LS-187274;2-Sulfamoyl-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran 7,7-dioxide;4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide7,7-dioxide;4-(Ethylamino)-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda~6~-thieno[2,3-b]thiopyran-2-sulfonamide

Suppliers and Price of 4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-Dorzolamide
50mg
$ 1020.00

American Custom Chemicals Corporation
(4-ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3B)THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE 95.00%
5MG
$ 496.40

Total 18 raw suppliers

Chemical Property of 4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide Edit

Chemical Property:

Boiling Point:575.8 °C at 760 mmHg
PKA:9.48±0.60(Predicted)
Flash Point:302 °C
PSA：151.33000
Density:1.53 g/cm³
LogP:3.86480
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:324.02722052
Heavy Atom Count:19
Complexity:534

Purity/Quality:

99% ^*data from raw suppliers

rac-Dorzolamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
Uses rac-Dorzolamide is an racemic mixture of Dorzolamide, an carbonic anhydrase inhibitor with antiglaucoma properties.

Technology Process of 4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

There total 2 articles about 4-(Ethylamino)-6-methyl-5,6-dihydro-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 120298-38-6
4?acetamido?5,6?dihydro?6?methyl?4H?thieno[2,3?b]thiopyran?2?sulfonamide?7,7?dioxide

: 149249-72-9,139066-77-6,120280-13-9
dorzolamide

Guidance literature:: 4?acetamido?5,6?dihydro?6?methyl?4H?thieno[2,3?b]thiopyran?2?sulfonamide?7,7?dioxide; With sodium tetrahydroborate; In tetrahydrofuran; at 5 - 10 ℃;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 10 - 45 ℃; for 8h;