10.1021/tx970134z
The research aimed to synthesize novel dithiocarbamate chelating agents to address cadmium intoxication and evaluate their effectiveness in cadmium decorporation. The study sought to develop compounds that were not only more effective but also less toxic than those previously reported. The chelating agents synthesized were disodium salts of N-glucamyl-N-dithiocarboxyl-amino acids, which included disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-threoninate and disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-cysteinate. These agents were found to be superior to sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (MeOBGDTC) in experiments, showing greater cadmium mobilizing properties and lower toxicity. The research concluded that these new dithiocarbamates were effective in both acute and repeated exposure cadmium poisoning, with minimal impact on the concentrations of essential metal ions in the renal cortex compared to a group treated with cadmium only. The study demonstrated the potential of these novel compounds as antidotes for cadmium intoxication.
10.1080/10426500802202063
The research investigates the reactions of naphthyl tellurium trihalides (ArTeX?, where X = Br, Cl and Ar = naphthyl) with various dithiocarbamate and xanthate ligands. The study explores the coordination chemistry of Te(II) and Te(IV) with these ligands, focusing on the formation of new naphthyl tellurium complexes. The chemicals involved include naphthyl tellurium trichloride and tribromide as starting materials, along with dithiocarbamate salts such as ammonium 1-pyrrolidinecarbodithioate and sodium dibenzyldithiocarbamate, and xanthate salts like potassium hexylxanthate. The reactions were carried out in solvents like tetrahydrofuran and methanol, resulting in the formation of naphthyl tellurium complexes with dithiocarbamate or xanthate ligands. The products were characterized using multinuclear NMR spectroscopy and elemental analysis, and the crystal structure of one of the complexes, naphthyl tellurium 1-pyrrolidinecarbodithioate, was determined by X-ray crystallography, revealing a three-coordinate T-shaped tellurium(II) geometry.
