1-methyl-2-p-chlorophenoxyethylamine

Base Information

• Chemical Name: 1-methyl-2-p-chlorophenoxyethylamine
• CAS No.: 23471-45-6
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.653
• Mol file: 23471-45-6.mol

Synonyms:1-methyl-2-p-chlorophenoxyethylamine

Chemical Property of 1-methyl-2-p-chlorophenoxyethylamine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Chloro-phenoxy)-1-methyl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-2-p-chlorophenoxyethylamine

There total 6 articles about 1-methyl-2-p-chlorophenoxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

→ 1-methyl-2-p-chlorophenoxyethylamine (23471-45-6)

Guidance literature:

With formamide; In water; at 185 ℃; for 4h;

Reference yield:

4-chlorophenoxyacetone oxime (104864-65-5) → 1-methyl-2-p-chlorophenoxyethylamine (23471-45-6)

Guidance literature:

With hydrogen; nickel; In diethyl ether; cyclohexane; at 45 ℃; for 18h; under 76000.1 Torr;

Reference yield:

4-chlorophenoxyacetone (18859-35-3) → 1-methyl-2-p-chlorophenoxyethylamine (23471-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl / pyridine / 3 h / Heating

2: LiAlH₄ / diethyl ether / 12 h / Heating

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; In pyridine; diethyl ether;

upstream raw materials:

4-chlorophenoxyacetone oxime

4-chlorophenoxyacetone

4-chloro-phenol

Downstream raw materials:

1-(4-chlorophenoxy)-2-propyl isocyanate

Refernces

• 1、 Li, Jian-Qiang,Wang, Zhi-Peng,Gao, Yang,Zhao, Wei-Guang. "Design, synthesis and effect of the introduction of a propargyloxy group on the fungicidal activities of 1-substituted phenoxypropan-2-amino valinamide carbamate derivatives". . p. 82131 - 82137. Retrieved 2016/09/09.
• 2、 Leclerc,Decker,Schwartz. "Derivatives related to betaxolol with α- and β-adrenergic activities". . p. 1357 - 1367. Retrieved 2007/10/02.