104864-65-5

Basic information

• Product Name: 4-chlorophenoxyacetone oxime
• Synonyms: 4-chlorophenoxyacetone oxime
• CAS NO: 104864-65-5
• Molecular Weight: 199.637
• Mol File: 104864-65-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chlorophenoxyacetone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenoxyacetone oxime(104864-65-5)
• EPA Substance Registry System: 4-chlorophenoxyacetone oxime(104864-65-5)

Safety Data

• Hazardous Substances Data: 104864-65-5(Hazardous Substances Data)

Upstream product

• 106-48-9 4-chloro-phenol 
• 18859-35-3 4-chlorophenoxyacetone 

Downstream Products

• 23471-46-7 1-(4-chlorophenoxy)-2-propanamine hydrochloride 
• 23471-45-6 1-methyl-2-p-chlorophenoxyethylamine 

Relevant articles and documents

Design, synthesis and effect of the introduction of a propargyloxy group on the fungicidal activities of 1-substituted phenoxypropan-2-amino valinamide carbamate derivatives

The cell walls of oomycetes are composed of cellulose, making cellulose synthase enzymes good targets for carboxylic acid amide fungicides. Valinamide carbamates are amino acid fungicides that represent excellent alternatives to conventional synthetic pesticides in terms of their ability to reduce the negative impacts of these compounds on human health and the environment. In a continuation of our research towards the development of new cellulose synthase inhibitors, we have developed a series of "stretched" analogues of iprovalicarb by the introduction of an additional OCH2 linker. The bioassay results indicated that compounds containing a small group at the para-position of phenyl gave excellent fungicidal activities with EC50 values ranging from 0.59 to 2.06 μmol L-1. Most notably, the introduction of a propargyloxy group led to a pronounced increase in the fungicidal activity. Furthermore, compound 7o bearing a propargyloxy group was identified as the most promising candidate because of its excellent fungicidal potency against oomycete diseases and good fungicidal activity against non-oomycete diseases.

Derivatives related to betaxolol with α- and β-adrenergic activities

The paper describes the synthesis and the pharmacological evaluation of some derivatives of betaxolol, all with an N-aralkylamine instead of the tertiobutylamine. These compounds have been tested for β1-adrenergic receptor antagonism on guinea pig atria, β2-adrenergic receptor antagonism on guinea pig trachea and α-adrenergic blocking activity on rat aorta. Compound U12 with a marked α-blocking activity and compound R8 with a β1/α ratio = 1 were selected for a haemodynamic study in the dog. The decrease in cardiac work and the diminution of total peripheral resistance exhibited by U12 are consistent with a dual α/β-blocking agent. Finally, structure-activity relationships are discussed.