diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

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Chemical Name:diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate
CAS No.:939387-86-7
Molecular Formula:C₂₆H₂₈N₃O₁₀PS
Molecular Weight:605.562
Hs Code.:

Synonyms:diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

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Chemical Property of diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

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Technology Process of diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

There total 5 articles about diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 636-98-6
p-nitrobenzene iodide

: 939387-55-0
diethyl (E)-3-(N-(benzyloxy)-N-(2-nitrobenzenesulfonyl)amino)-1-(tributyl-stannyl)-propenylphosphonate

: 939387-86-7
diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

Guidance literature:: With copper(l) iodide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; trifuran-2-yl-phosphane; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 939387-56-1
diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]prop-1-ynylphosphonate

: 939387-86-7
diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

Guidance literature:: diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]prop-1-ynylphosphonate; With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

p-nitrobenzene iodide; With copper(l) iodide; trifuran-2-yl-phosphane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1-methyl-pyrrolidin-2-one; at 20 ℃; Further stages.;
DOI:10.1021/jo0700981

Reference yield:

: diethyl (3-(tetrahydro-2H-pyran-2-yl)oxy)prop-1-yn-1-ylphosphonate

: 939387-86-7
diethyl 3-[N-benzyloxy-N-(2-nitrobenzenesulfonyl)amino]-1-(4-nitrophenyl)prop-1-enylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 8.75 g / p-TsOH / methanol / 20 °C

2.1: 71 percent / DEAD; PPh₃ / tetrahydrofuran / 20 h / 20 °C

3.1: Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: 98 mg / (2-furyl)3P; CuI / Pd₂dba3*CHCl₃ / 1-methyl-pyrrolidin-2-one / 20 °C

With tri-n-butyl-tin hydride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 2.1: Mitsunobu coupling / 3.2: Stille coupling;
DOI:10.1021/jo0700981