erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione

Base Information

• Chemical Name: erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione
• CAS No.: 85260-59-9
• Molecular Formula: C₂₁H₂₃NO₂S₂
• Molecular Weight: 385.551
• Mol file: 85260-59-9.mol

Synonyms:erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione

Chemical Property of erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione

There total 3 articles about erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-phenyl-propionaldehyde (104-53-0) + 3-phenyl-1-(2-thioxothiazolidin-3-yl)propan-1-one (65439-56-7) → erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione (85260-59-9)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1246/cl.1982.1903

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + 3-phenyl-1-(2-thioxothiazolidin-3-yl)propan-1-one (65439-56-7) → threo-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione (85260-59-9) + erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione (85260-59-9)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + 3-phenyl-1-(2-thioxothiazolidin-3-yl)propan-1-one (65439-56-7) → threo-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione (85260-59-9) + erythro-3-(2-benzyl-3-hydroxy-5-phenylpentanoyl)thiazolidine-2-thione (85260-59-9)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.333333h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

upstream raw materials:

3-phenyl-propionaldehyde

3-phenyl-1-(2-thioxothiazolidin-3-yl)propan-1-one

Downstream raw materials:

(2R,3S)-2-Benzyl-3-hydroxy-5-phenyl-pentanoic acid methyl ester