methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

Base Information

Chemical Name:methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate
CAS No.:1258270-83-5
Molecular Formula:C₁₉H₂₂F₃NO₇
Molecular Weight:433.381
Hs Code.:

Synonyms:methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

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Chemical Property of methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

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Technology Process of methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

There total 10 articles about methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl 5-methoxy-2-[N-(2,4,5-trihydroxypent-2-enyl)trifluoroacetamido]benzoate

: 77-76-9
2,2-dimethoxy-propane

: 1258270-83-5
methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 40 ℃; for 16h;
DOI:10.1021/jo101834c

Reference yield:

: 1258270-80-2
methyl 2-(2-acetoxypent-4-enylamino)-5-methoxybenzoate

: 1258270-83-5
methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / methanol / 1 h / 20 °C

2: dmap / dichloromethane / 40 h / 20 °C

3: pyridine / 1.5 h / 0 °C

4: trifluoroacetic acid / dichloromethane / 0.42 h / 20 °C

5: Dess-Martin periodane / dichloromethane / 1 h

6: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 30 h / 20 °C

7: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 40 °C

With pyridine; dmap; osmium(VIII) oxide; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; trifluoroacetic acid; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jo101834c

Reference yield:

: 1258270-95-9
methyl 2-(2-(tert-butoxycarbonyloxy)pent-4-enylamino)-5-methoxybenzoate

: 1258270-83-5
methyl 2-[N-(3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-oxopropyl)trifluoroacetamido]-5-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 1.5 h / 0 °C

2: trifluoroacetic acid / dichloromethane / 0.42 h / 20 °C

3: Dess-Martin periodane / dichloromethane / 1 h

4: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone / 30 h / 20 °C

5: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 40 °C

With pyridine; osmium(VIII) oxide; pyridinium p-toluenesulfonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; trifluoroacetic acid; In dichloromethane; water; acetone;
DOI:10.1021/jo101834c