(S)-Methylone

Base Information

• Chemical Name: (S)-Methylone
• CAS No.: 191916-41-3
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 191916-41-3.mol

Synonyms:1-Propanone,1-(1,3-benzodioxol-5-yl)-2-(methylamino)-, (S)- (9CI)

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Chemical Property of (S)-Methylone

Chemical Property:

• Boiling Point: 350.1±42.0 °C(Predicted)
• PKA: 7.74±0.10(Predicted)
• PSA: 47.56000
• Density: 1.188
• LogP: 1.59680

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-Methylone

There total 6 articles about (S)-Methylone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methylone hydrochloride → 1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one (186028-79-5,191916-41-3)

Guidance literature:

With potassium carbonate; In water; at 20 ℃;

DOI:10.1016/j.molstruc.2011.06.030

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one (186028-79-5,191916-41-3) → S-(+)-methylone (186028-79-5,191916-41-3) + R-(+)-methylone (186028-79-5,191916-41-3)

Guidance literature:

With Lux i-Amylose-1 column; In hexane; diethylamine; isopropyl alcohol; at 20 ℃; Resolution of racemate;

DOI:10.1002/chir.23135

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one (186028-79-5,191916-41-3) → S-(+)-methylone (186028-79-5,191916-41-3) + R-(+)-methylone (186028-79-5,191916-41-3)

Guidance literature:

With Lux i-Amylose-1 column; In hexane; diethylamine; isopropyl alcohol; at 20 ℃; Resolution of racemate;

DOI:10.1002/chir.23135

upstream raw materials:

1-(3,4-(methylenedioxy)phenyl)-2-bromopropan-1-one

methylamine

3,4-methylenedioxypropiophenone

Methylenedioxybenzene

Downstream raw materials:

S-(+)-methylone

R-(+)-methylone

3,4-Methylenedioxycathinone

3,4-dihydroxymethcathinone

Refernces

• 1、 Bak, Andrzej,Kozik, Violetta,Kozakiewicz, Dariusz,Gajcy, Kamila,Strub, Daniel Jan,Swietlicka, Aleksandra,Stepankova, Sarka,Imramovsky, Ales,Polanski, Jaroslaw,Smolinski, Adam,Jampilek, Josef. "Novel benzene-based carbamates for ache/bche inhibition: Synthesis and ligand/structure-oriented sar study". . . Retrieved 2019/05/10.