Technology Process of (R)-benzyl 1-(1-amino-2-methylallyl)cyclopropylcarbamate hydrochloride
There total 5 articles about (R)-benzyl 1-(1-amino-2-methylallyl)cyclopropylcarbamate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; methanol;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
3: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h
4: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
2: titanium(IV) tetraethanolate / tetrahydrofuran / 4 h
3: tetrahydrofuran; dichloromethane / 1 h / 0 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium aluminium tetrahydride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
