84677-06-5

Basic information

• Product Name: 1-(Cbz-amino)cyclopropanecarboxylic acid
• Synonyms: N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic;Cyclopropanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]- (9CI);1-(z-amino)cyclopropanecarboxylic acid;1-(Cbz-amino)cyclopropanecarboxylic acid;N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic acid;1-Benzyloxycarbonylaminocyclopropanecarboxylic acid;CBZ-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;Cbz-ACPC-OH
• CAS NO: 84677-06-5
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Product Categories: N-CBZ;Amino Acid Derivatives;Amino Acids;I - Z;Modified Amino Acids
• Mol File: 84677-06-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 157.0 to 161.0 °C
• Boiling Point: 449oC at 760 mmHg
• Flash Point: 225.4oC
• Appearance: /
• Density: 1.33g/cm3
• Vapor Pressure: 7.55E-09mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: −20°C
• Solubility: soluble in Methanol
• PKA: 4.02±0.20(Predicted)
• CAS DataBase Reference: 1-(Cbz-amino)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Cbz-amino)cyclopropanecarboxylic acid(84677-06-5)
• EPA Substance Registry System: 1-(Cbz-amino)cyclopropanecarboxylic acid(84677-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 84677-06-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic Acid is a useful intermediate used in the preparation of the analogs of vasopressins and other peptide derivatives.

InChI:InChI=1/C12H13NO4/c14-10(15)12(6-7-12)13-11(16)17-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,13,16)(H,14,15)

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 501-53-1 benzyl chloroformate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 84677-05-4 methyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate 
• 68781-13-5 α-amino-cyclopropanecarboxylic acid hydrochloride 
• 76338-91-5 2-<(benzyloxycarbonyl)amino>-4-bromobutanoic acid methyl ester 

Downstream Products

• 84677-05-4 methyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate 
• 108056-97-9 N-(benzyloxycarbonyl)-1-aminocyclopropane-1-carboxamide 
• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 91682-45-0 Benzyloxycarbonyl-1-aminocyclopropane-1-carboxy-leucyl-glycine Ethyl Ester 
• 130831-96-8 pentafluorophenyl benzyloxycarbonyl-1-aminocyclopropane-1-carboxylate 
• 145122-58-3 1-Benzyloxycarbonylamino-cyclopropanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 1616347-62-6 (7R)-7-[3,5-bis(trifluoromethyl)phenyl]-6-oxa-4-azaspiro[2.4]heptan-5-one 
• 1616347-63-7 (7S)-7-[3,5-bis(trifluoromethyl)phenyl]-6-oxa-4-azaspiro[2.4]heptan-5-one 
• 1616347-66-0 7-[3,5-bis(trifluoromethyl)phenyl]-6-oxa-4-azaspiro[2.4]heptan-5-one 
• 1616347-65-9 benzyl (1-{[3,5-bis(trifluoromethyl)phenyl](hydroxy)methyl} cyclopropyl)carbamate 
• 1616347-64-8 benzyl (1-{[3,5-bis(trifluoromethyl)phenyl]carbonyl}cyclopropyl)carbamate 
• 851726-81-3 benzyl {1-[methoxy(methyl)carbamoyl]cyclopropyl}carbamate 

Relevant articles and documents

Trimethyl-substituted carbamate as a versatile self-immolative linker for fluorescence detection of enzyme reactions

Self-immolative linker is a useful building block of molecular probes, with broad applications in the fields of enzyme activity analysis, stimuli-responsive material science, and drug delivery. This manuscript presents N-methyl dimethyl methyl (i.e., trimethyl) carbamate as a new class of self-immolative linker for the fluorescence detection of enzyme reactions. The trimethyl carbamate was shown to spontaneously undergo intramolecular cyclization upon formation of a carboxylate group, to liberate a fluorophore with the second time rapid reaction kinetics. Interestingly, the auto-cleavage reaction of trimethyl carbamate was also induced by the formation of hydroxyl and amino groups. Fluorescent probes with a trimethyl carbamate could be applicable for fluorescence monitoring of the enzyme reactions catalyzed by esterase, ketoreductase, and aminotransferase, and for fluorescence imaging of intracellular esterase activity in living cells, hence demonstrating the utility of this new class of self-immolative linker.

NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.