(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:450409-01-5
Molecular Formula:C₂₇H₂₃NO₆
Molecular Weight:457.483
Hs Code.:

Synonyms:(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of (E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 3 articles about (E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 54429-62-8
(E)-3-(3,4-bis(benzyloxy)phenyl)acrylic acid

: 450409-01-5
(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 25 ℃; for 13h;
DOI:10.1246/Cl.2005.264

Reference yield:

: 5447-02-9
3,4-dibenzyloxybenzaldehyde

: 450409-01-5
(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 10 h / Heating

2: aq. NaOH / dimethylsulfoxide; methanol / 12.5 h / 0 - 25 °C

3: 83 percent / N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; dimethylformamide / 13 h / 0 - 25 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Wittig reaction;
DOI:10.1246/Cl.2005.264

Reference yield:

: 71038-25-0
methyl (E)-3-(3,4-bis(benzyloxy)phenyl)acrylate

: 450409-01-5
(E)-3-(3,4-Bis-benzyloxy-phenyl)-acrylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / dimethylsulfoxide; methanol / 12.5 h / 0 - 25 °C

2: 83 percent / N,N'-dicyclohexylcarbodiimide / tetrahydrofuran; dimethylformamide / 13 h / 0 - 25 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1246/Cl.2005.264