1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

Base Information

Chemical Name:1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane
CAS No.:1395576-91-6
Molecular Formula:C₂₁H₂₈ClN₃
Molecular Weight:357.926
Hs Code.:

Synonyms:1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

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Chemical Property of 1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

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Technology Process of 1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

There total 2 articles about 1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 100-69-6,25014-15-7,27476-03-5,329041-71-6
2-vinylpyridine

: 1395577-09-9
1-[2-(4-chlorophenyl)ethyl]-1,5-diazabicyclooctane

: 1395576-91-6
1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

Guidance literature:: With acetic acid; In methanol; for 24h; Reflux;
DOI:10.1021/ic301272h

Reference yield:

: 6529-53-9
1-(2-bromoethyl)-4-chlorobenzene

: 40422-46-6
1,5-diazabicyclooctane dihydrobromide

: 1395576-91-6
1-[2-(4-chlorophenyl)ethyl]-5-[2-(2-pyridyl)ethyl]-1,5-diazabicyclooctane

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; triethylamine / acetonitrile; water / 14 h / Reflux

2: acetic acid / methanol / 24 h / Reflux

With acetic acid; triethylamine; potassium hydroxide; In methanol; water; acetonitrile; 2: |Michael Addition;
DOI:10.1021/ic301272h