5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane

Base Information

• Chemical Name: 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane
• CAS No.: 420107-83-1
• Molecular Formula: C₂₆H₂₅F₁₇N₂O₆
• Molecular Weight: 784.467
• Mol file: 420107-83-1.mol

Synonyms:5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane

Chemical Property of 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane

There total 4 articles about 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl isocyanate (142010-50-2) + (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol (420107-80-8) → 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane (420107-83-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; for 6h; pH=8 - 9; Heating;

DOI:10.1039/b104958p

Reference yield:

4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanoylchloride (89373-67-1) → 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane (420107-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaN₃ / acetone; H₂O / 10 - 15 °C

1.2: 62 percent / cyclohexane

2.1: 92 percent / diazabicyclooctane / toluene / 6 h / pH 8 - 9 / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; sodium azide; In water; acetone; toluene; 1.2: Curtius Rearrangement;

DOI:10.1039/b104958p

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane (420107-83-1)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / acetonitrile; H₂O

2: APTS / CH₂Cl₂

3: 92 percent / diazabicyclooctane / toluene / 6 h / pH 8 - 9 / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydroxide; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In dichloromethane; water; toluene; acetonitrile;

DOI:10.1039/b104958p

upstream raw materials:

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl isocyanate

(5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanoylchloride

benzyl chloroformate

Downstream raw materials:

N-(benzyloxycarbonyl)-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethylbis(hydroxymethyl)aminomethane