Technology Process of 1,6-anhydro-2,3-di-O-benzyl-4-O-(2,3-di-O-benzyl-6-deoxy-α-D-galactopyranosyl)-β-D-glucopyranose
There total 8 articles about 1,6-anhydro-2,3-di-O-benzyl-4-O-(2,3-di-O-benzyl-6-deoxy-α-D-galactopyranosyl)-β-D-glucopyranose which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) 0.42 M methanolic sodium methoxide; 2.) sodium hydride / 1.) methanol, r.t., overnight; 2.) DMF, r.t., 30 min; 3.) r.t., 3 h
2: 63 percent / water, acetic acid / 0.5 h / 97 - 98 °C
3: 74 percent / 1.) triphenylphosphine, N-iodosuccinimide / 1.) DMF, 50 deg C, 3 h; 2.) DMF, methanol, r.t., 1 h
4: 80 percent / lithium aluminium hydride / various solvent(s) / 2 h / Ambient temperature
5: 93 percent / pyridine; CH2Cl2 / 48 h / Ambient temperature
6: 1.) sodium benzoate; 2.) 2 M aqueous sodium hydroxide / 1.) hexamethylphosphoric triamide, 120-130 deg C, 16 h; 2.) methanol, r.t., overnight
With
sodium benzoate; sodium hydroxide; N-iodo-succinimide; lithium aluminium tetrahydride; water; sodium methylate; sodium hydride; acetic acid; triphenylphosphine;
In
pyridine; dichloromethane;
DOI:10.1016/0008-6215(83)88173-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) 0.42 M methanolic sodium methoxide; 2.) sodium hydride / 1.) methanol, r.t., overnight; 2.) DMF, r.t., 30 min; 3.) r.t., 3 h
2: 63 percent / water, acetic acid / 0.5 h / 97 - 98 °C
3: 74 percent / 1.) triphenylphosphine, N-iodosuccinimide / 1.) DMF, 50 deg C, 3 h; 2.) DMF, methanol, r.t., 1 h
4: 80 percent / lithium aluminium hydride / various solvent(s) / 2 h / Ambient temperature
5: 93 percent / pyridine; CH2Cl2 / 48 h / Ambient temperature
6: 1.) sodium benzoate; 2.) 2 M aqueous sodium hydroxide / 1.) hexamethylphosphoric triamide, 120-130 deg C, 16 h; 2.) methanol, r.t., overnight
With
sodium benzoate; sodium hydroxide; N-iodo-succinimide; lithium aluminium tetrahydride; water; sodium methylate; sodium hydride; acetic acid; triphenylphosphine;
In
pyridine; dichloromethane;
DOI:10.1016/0008-6215(83)88173-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / lithium aluminium hydride / various solvent(s) / 2 h / Ambient temperature
2: 93 percent / pyridine; CH2Cl2 / 48 h / Ambient temperature
3: 1.) sodium benzoate; 2.) 2 M aqueous sodium hydroxide / 1.) hexamethylphosphoric triamide, 120-130 deg C, 16 h; 2.) methanol, r.t., overnight
With
sodium benzoate; sodium hydroxide; lithium aluminium tetrahydride;
In
pyridine; dichloromethane;
DOI:10.1016/0008-6215(83)88173-7
