3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

Base Information

Chemical Name:3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile
CAS No.:122376-77-6
Molecular Formula:C₂₂H₁₅N₃O₂
Molecular Weight:353.38
Hs Code.:

Synonyms:3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

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Technology Process of 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

There total 3 articles about 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 5332-26-3
N-(bromomethyl)phtalimide

: 5005-36-7
phenyl-pyridin-2-yl-acetonitrile

: 122376-77-6
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) r.t., 1 h, 2.) 80 deg C, 1 h;
DOI:10.1002/ardp.19893220310

Reference yield:

: 109-09-1
2-chloropyridine

: 122376-77-6
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NaNH₂ / toluene

2: 81 percent / 1.) NaH / dimethylformamide / 1.) r.t., 1 h, 2.) 80 deg C, 1 h

With sodium hydride; sodium amide; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.19893220310

Reference yield:

: 140-29-4
phenylacetonitrile

: 122376-77-6
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-2-pyridin-2-yl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: NaNH₂ / toluene

2: 81 percent / 1.) NaH / dimethylformamide / 1.) r.t., 1 h, 2.) 80 deg C, 1 h

With sodium hydride; sodium amide; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/ardp.19893220310