N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

Base Information

• Chemical Name: N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
• CAS No.: 1374606-88-8
• Molecular Formula: C₁₅H₂₂BNO₄
• Molecular Weight: 291.155
• Mol file: 1374606-88-8.mol

Synonyms:N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

Chemical Property of N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

There total 1 articles about N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-methoxyacetanilide (51-66-1) + bis(pinacol)diborane (73183-34-3) → N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (1374606-88-8)

Guidance literature:

With BQ; palladium diacetate; In acetic acid; 5 % Pd(OAc)2, 2 equiv (Bpin)2, 2 equiv BQ, 33%TsOH-AcOH, PfhCF3, 30°C;

DOI:10.1039/c2cc31737k

Reference yield: 95.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (1374606-88-8) → N-(4-methoxy-2-(thiazol-2-yl)phenyl)acetamide (1374606-92-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; In ethanol; water; at 100 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c2cc31737k

Reference yield: 62.0%

N-(4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (1374606-88-8) + Umemoto's reagent → N-[4-methoxy-2-(trifluoromethyl)phenyl]acetamide (142955-44-0)

Guidance literature:

With 2,4,6-trimethyl-pyridine; copper(I) thiophene-2-carboxylate; potassium hydroxide; In N,N-dimethyl acetamide; at 80 ℃; chemoselective reaction;

DOI:10.1039/c2cc31737k

upstream raw materials:

4-methoxyacetanilide

bis(pinacol)diborane

Downstream raw materials:

N-(4-methoxy-2-(thiazol-2-yl)phenyl)acetamide

N-[4-methoxy-2-(trifluoromethyl)phenyl]acetamide